Radiotherapy planning for glioblastoma based on a tumor growth model: improving target volume delineation
نویسندگان
چکیده
منابع مشابه
Radiotherapy planning for glioblastoma based on a tumor growth model: improving target volume delineation.
Glioblastoma differ from many other tumors in the sense that they grow infiltratively into the brain tissue instead of forming a solid tumor mass with a defined boundary. Only the part of the tumor with high tumor cell density can be localized through imaging directly. In contrast, brain tissue infiltrated by tumor cells at low density appears normal on current imaging modalities. In current cl...
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Radiotherapy treatment planning requires a localization of the tumor within the patient. This is challenging to accomplish for microscopic infiltrative spread of disease that is not visible on current imaging modalities. Prime examples for infiltrative tumors are gliomas. With the help of mathematical models, common growth characteristics of gliomas, which are known from histopathological studi...
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Gliomas differ from many other tumors as they grow infiltratively into the brain parenchyma rather than forming a solid tumor mass with a well-defined boundary. Tumor cells can be found several centimeters away from the central tumor mass that is visible using current imaging techniques. The infiltrative growth characteristics of gliomas question the concept of a radiotherapy target volume that...
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BACKGROUND This study compared manually delineated gross tumour volume (GTV) and automatically generated biological tumour volume (BTV) based on fluoro-deoxy-glucose (FDG) positron emission tomography (PET)/CT to assess the robustness of predefined PET algorithms for radiotherapy (RT) planning in routine clinical practice. METHODS RT-planning data from 20 consecutive patients (lung- (40%), oe...
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ژورنال
عنوان ژورنال: Physics in Medicine and Biology
سال: 2014
ISSN: 0031-9155,1361-6560
DOI: 10.1088/0031-9155/59/3/747